Sim City creator, Will Wright, has a new sim in the making, Spore. (thanks bt!)
Spore is a sim that allows the players to control life on all conceivable scales--an emergent and beautiful simulation game that ranges from the cellular level all the way to the galactic level.
From stonz (emphasis mine):
"The game allows the player to begin with developing a creature as a cellular entity and eventually creating a creature with more sophisticated brain functions, which will change the nature of the game to a more RTS-type game (he cited a particular favorite of his, Populous), where players will control herds of creatures. Once you upgrade the "hut" around which the creatures centralize, the game changes into what he called "a simple version of SimCity" where the player manages technology and interacts with other cities that have sprung up around the world."
Like stonz sez: Cutting too close to home, man. Too close.